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Ernesto Schiffrin Hypertension Challenges, Future Directions
Results Summary (1)

Atenolol-based therapy was associated with higher central aortic systolic pressure and higher central aortic pulse pressure, despite similar brachial pressures, when compared with amlodipine-based therapy
Central aortic outgoing pressure wave (P1 height) was lower with atenolol-based therapy vs amlodipine-based therapy
Pulse wave augmentation and the percentage of the central aortic pressure wave attributable to wave reflection was increased by atenolol-based therapy compared with amlodipine-based therapy

CAFE Study Conclusions (2)

Brachial blood pressure overestimated the hemodynamic benefit of atenolol ± thiazide-based treatment and underestimated the benefit of amlodipine ± perindopril-based treatment on central aortic pressures and hemodynamics
Central aortic pressure may be an important independent determinant of clinical outcomes
Results of the CAFE study suggest thar the “central aortic blood pressure hypothesis” is a plausible mechanism to explain the better clinical outcomes for hypertensive patients treated with amlodipine ± perindopril-based theraphy in ASCOT